{"id":331,"date":"2023-01-19T10:54:15","date_gmt":"2023-01-19T10:54:15","guid":{"rendered":"https:\/\/staging.for2799.de\/?page_id=331"},"modified":"2023-02-16T17:02:11","modified_gmt":"2023-02-16T16:02:11","slug":"our-goals","status":"publish","type":"page","link":"https:\/\/www.for2799.de\/our-goals\/","title":{"rendered":"Our Goals"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=”1\/2″][vc_column_text]<\/p>\n<h6>Receiving and Translating Signals via the \u03b3\u03b4 T Cell Receptor<\/h6>\n<p>\u03b3\u03b4 T cells were discovered over 30 years ago. However, in contrast to their MHC-restricted \u03b1\u03b2 T cell counterparts, their place in cellular immunity of vertebrates is not yet defined. Over the past few \u00a0years, the visibility and scientific output of the \u03b3\u03b4 T cell field has \u00a0rapidly gained momentum due to outstanding new findings regarding the \u00a0identification of potential ligands for the \u03b3\u03b4 TCR, insights into the role of \u03b3\u03b4 T cells in the control of infectious diseases, and due to the \u00a0recognition of \u03b3\u03b4 T cells as a potential cellular therapy against \u00a0tumors. Thus, \u03b3\u03b4 T cell research is a hot topic with a lot of potential \u00a0for translation into clinical application. Notably, several German research groups have recently contributed important new findings to the \u03b3\u03b4 T cell field. Together, we are therefore confident that that it is the right time to join our forces within the frame of a DFG Research Unit.<\/p>\n<p>In this proposal, we hypothesize that recognition of cognate \u00a0antigen via the \u03b3\u03b4 TCR leads to intracellular signal transduction and \u03b3\u03b4 \u00a0T cell activation, differentiation and execution of effector functions, \u00a0and activated \u03b3\u03b4 T cells proliferate and thereby focus the \u03b3\u03b4 T cell \u00a0repertoire. The specific aims of this consortium are to cooperatively \u00a0monitor and define how \u03b3\u03b4 T cells participate in immune responses against cancer and infections, to better understand how the \u03b3\u03b4 TCR is \u00a0activated, and to investigate the consequences of \u03b3\u03b4 T cell activation. To this end, our portfolio ranges from clinical observational studies to \u00a0the investigation of basic biochemical questions and from experimental \u00a0in vivo studies back to translational clinical approaches. We will exchange and jointly apply our complementary experimental systems and \u00a0further push forward novel technologies such as high-resolution TCR \u00a0repertoire analysis, high-dimensional phenotypic analysis by multi-parameter and mass cytometry and single cell RNA sequencing to \u00a0understand how the \u03b3\u03b4 TCR receives and transduces external signals.<br \/>\nOn \u00a0the long run, the overarching goals of FOR 2799 will be i) to increase \u00a0the visibility of German \u03b3\u03b4 T cell research, ii) to identify how \u03b3\u03b4 T \u00a0cells respond to neoplastic and infected cells and iii) to explore how \u00a0our knowledge on \u03b3\u03b4 T cell activation can be translated into clinical strategies for their in vivo manipulation, e.g. in anti-tumor therapy.[\/vc_column_text][\/vc_column][vc_column width=”1\/2″][vc_single_image image=”330″][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=”1\/2″][vc_column_text] Receiving and Translating Signals via the \u03b3\u03b4 T Cell Receptor \u03b3\u03b4 T cells were discovered over 30 years ago. However, in contrast to their MHC-restricted \u03b1\u03b2 T cell counterparts, their place in cellular immunity of vertebrates is not yet defined. Over the past few \u00a0years, the visibility and scientific output of the \u03b3\u03b4 …<\/p>\n","protected":false},"author":1,"featured_media":334,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-331","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.for2799.de\/wp-json\/wp\/v2\/pages\/331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.for2799.de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.for2799.de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.for2799.de\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.for2799.de\/wp-json\/wp\/v2\/comments?post=331"}],"version-history":[{"count":9,"href":"https:\/\/www.for2799.de\/wp-json\/wp\/v2\/pages\/331\/revisions"}],"predecessor-version":[{"id":540,"href":"https:\/\/www.for2799.de\/wp-json\/wp\/v2\/pages\/331\/revisions\/540"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.for2799.de\/wp-json\/wp\/v2\/media\/334"}],"wp:attachment":[{"href":"https:\/\/www.for2799.de\/wp-json\/wp\/v2\/media?parent=331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}