Publications

A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood. Tan, L., Fichtner, A. S., Bruni, E., Odak, I., Sandrock, I., Bubke, A., Borchers, A., Schultze-Florey, C., Koenecke, C., Förster, R., Jarek, M., von Kaisenberg, C., Schulz, A., Chu, X., Zhang, B., Li, Y., Panzer, U., Krebs, C. F., Ravens, S., & Prinz, I. Sci. Immunol. 2021; 6: eabf0125.

Genetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults. Beucke N, Wingerter S, Hähnel K, Larsen LA, Christensen K, Pawelec G, Wistuba-Hamprecht K. Cells 2021; 10:373.

Direct Regulation of the T Cell Antigen Receptors’s Activity by Cholesterol. Pathan-Chhatbar S, Drechsler C, Richter K, Morath A, Wu W, OuYang B, Xu C, Schamel WW. Front Cell Dev Bio. 2021;8:615996.

Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells upon puberty promotes local tissue immune surveillance. Wilharm A, Brigas HC, Sandrock I, Ribeiro M, Amado T, Reinhardt A, Demera A, Hoenicke L, Strowig T, Carvalho T, Prinz I, Ribot JC. Mucosal Immunol. 2021;14:242-252. 

Reply to: Vitamin C as a promoter of γδ T cells. Kouakanou L, Peters C, Kabelitz D.  Cell Mol Immunol. 2021;18:495.

Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer. Xu Y, Xiang Z, Alnaggar M, Kouakanou L, Li J, He J, Yang J, Hu Y, Chen Y, Lin L, Hao J, Li J, Chen J, Li M, Wu Q, Peters C, Zhou Q, Li J, Liang Y, Wang X, Han B, Ma M, Kabelitz D, Xu K, Tu W, Wu Y, Yin Z. Cell Mol Immunol. 2021;18:427-439. Beucke, N.; Wingerter, S.; Hähnel, K.; Larsen, L.A.; Christensen, K.; Pawelec, G.; Wistuba-Hamprecht, K. Genetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults. Cells 2021, 10, 3

TCR repertoire analysis reveals phosphoantigen-induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults. Fichtner AS, Bubke A, Rampoldi F, Wilharm A, Tan L, Steinbrück L, Schultze-Florey C, von Kaisenberg C, Prinz I, Herrmann T, Ravens S. J Leukoc Biol. 2020;107:1023-1032. 

Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset. Fichtner AS, Karunakaran MM, Gu S, Boughter CT, Borowska MT, Starick L, Nöhren A, Göbel TW, Adams EJ, Herrmann T. Proc Natl Acad Sci U S A. 2020;117:6697-6707. 

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing. Karunakaran MM, Willcox CR, Salim M, Paletta D, Fichtner AS, Noll A, Starick L, Nöhren A, Begley CR, Berwick KA, Chaleil RAG, Pitard V, Déchanet-Merville J, Bates PA, Kimmel B, Knowles TJ, Kunzmann V, Walter L, Jeeves M, Mohammed F, Willcox BE, Herrmann T. Immunity. 2020;52:487-498. 

An Update on the Molecular Basis of Phosphoantigen Recognition by Vγ9Vδ2 T Cells. Herrmann T, Fichtner AS, Karunakaran MM. Cells. 2020;9:1433. 

A glance over the fence: Using phylogeny and species comparison for a better understanding of antigen recognition by human γδ T-cells. Herrmann T, Karunakaran MM, Fichtner AS. Immunol Rev. 2020;298:218-236. 

Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth.

Ravens S, Fichtner AS, Willers M, Torkornoo D, Pirr S, Schöning J, Deseke M, Sandrock I, Bubke A, Wilharm A, Dodoo D, Egyir B, Flanagan KL, Steinbrück L, Dickinson P, Ghazal P, Adu B, Viemann D, Prinz I. Proc Natl Acad Sci U S A. 2020;117:18649-18660. 

Human γδ TCR Repertoires in Health and Disease. Fichtner AS, Ravens S, Prinz I. Cells. 2020;9:800. 

From basic research to clinical application of γδ T cells. Déchanet-Merville J, Prinz I.

Immunol Rev. 2020;298:5-9. 

Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions. Deseke M, Prinz I. Cell Mol Immunol. 2020 Sep;17(9):914-924. 

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies. Sebestyen Z, Prinz I, Déchanet-Merville J, Silva-Santos B, Kuball J. Nat Rev Drug Discov. 2020;19:169-184. 

Dangerous γδ T cells in aged mice. Prinz I, Sandrock I. EMBO Rep. 2019;20:e48678.

αβ and γδ T cell receptors: Similar but different. Morath A, Schamel WW. J Leukoc Biol. 2020;107:1045-1055. 

Galectin-3 Released by Pancreatic Ductal Adenocarcinoma Suppresses γδ T Cell Proliferation but Not Their Cytotoxicity. Gonnermann D, Oberg HH, Lettau M, Peipp M, Bauerschlag D, Sebens S, Kabelitz D, Wesch D. Front Immunol. 2020;11:1328. 

Influence of Indoleamine-2,3-Dioxygenase and Its Metabolite Kynurenine on γδ T Cell Cytotoxicity against Ductal Pancreatic Adenocarcinoma Cells. Jonescheit H, Oberg HH, Gonnermann D, Hermes M, Sulaj V, Peters C, Kabelitz D, Wesch D.Cells. 2020;9:1140. 

Pitfalls in the characterization of circulating and tissue-resident human γδ T cells. Beucke N, Wesch D, Oberg HH, Peters C, Bochem J, Weide B, Garbe C, Pawelec G, Sebens S, Röcken C, Hashimoto H, Löffler MW, Nocerino P, Kordasti S, Kabelitz D, Schilbach K, Wistuba-Hamprecht K. J Leukoc Biol. 2020;107:1097-1105. 

Bispecific antibodies enhance tumor-infiltrating T cell cytotoxicity against autologous HER-2-expressing high-grade ovarian tumors. Oberg HH, Janitschke L, Sulaj V, Weimer J, Gonnermann D, Hedemann N, Arnold N, Kabelitz D, Peipp M, Bauerschlag D, Wesch D. J Leukoc Biol. 2020;107:1081-1095. 

Tumor resistance mechanisms and their consequences on γδ T cell activation. Wesch D, Kabelitz D, Oberg HH. Immunol Rev. 2020;298:84-98. 

Resolving the mystery-How TCR transgenic mouse models shed light on the elusive case of gamma delta T cells. Hahn AM, Winkler TH. J Leukoc Biol. 2020;107:993-1007. 

Accurate determination of γδ T cells in multi-channel mass and flow cytometry. Beucke N, Wistuba-Hamprecht K. Cytometry B Clin Cytom. 2020. 

Immune Signatures and Survival of Patients With Metastatic Melanoma, Renal Cancer, and Breast Cancer. Wistuba-Hamprecht K, Gouttefangeas C, Weide B, Pawelec G. Front Immunol. 2020;11:1152.

Cancer immunotherapy with γδ T cells: many paths ahead of us. Kabelitz D, Serrano R, Kouakanou L, Peters C, Kalyan S. Cell Mol Immunol. 2020;17:925-939. 

Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation. Kouakanou L, Peters C, Sun Q, Floess S, Bhat J, Huehn J, Kabelitz D. Sci Rep. 2020;10:6550. 

A comparative view on vitamin C effects on αβ- versus γδ T-cell activation and differentiation. Peters C, Kouakanou L, Kabelitz D.  J Leukoc Biol. 2020;107:1009-1022. 

Vitamin C promotes the proliferation and effector functions of human γδ T cells. Kouakanou L, Xu Y, Peters C, He J, Wu Y, Yin Z, Kabelitz D. Cell Mol Immunol. 2020;17:462-473. 

High-throughput analysis of the human thymic Vδ1+ T cell receptor repertoire.Di Lorenzo B, Ravens S, Silva-Santos B. Sci Data. 2019;6:115. 

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells.Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ, Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav AH, Krebs C, Prinz I, Ravens S. Cell Rep. 2019;27:3657-3671.e4. 

Styk1 is specifically expressed in NK1.1+ lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function. Wilharm A, Sandrock I, Marotel M, Demera A, Naumann R, Walzer T, Prinz I. Eur J Immunol. 2019;49:686-693.

TRAIL-Receptor 4 Modulates γδ T Cell-Cytotoxicity Toward Cancer Cells. Tawfik D, Groth C, Gundlach JP, Peipp M, Kabelitz D, Becker T, Oberg HH, Trauzold A, Wesch D. Front Immunol. 2019;10:2044. 

The TCR is an allosterically regulated macromolecular machinery changing its conformation while working. Schamel WW, Alarcon B, Minguet S. Immunol Rev. 2019;291:8-25.