Decoding immune mechanisms in spondyloarthropathies—unraveling γδ T cell-driven inflammation

We investigate the immune mechanisms underlying chronic inflammatory diseases, with a focus on spondyloarthropathies (SpA) and the role of γδ T cells in disease progression. Despite its success in related conditions, the failure of IL-23R inhibition in SpA highlights the need to better understand the distinct pathways driving inflammation and tissue damage. Using murine models, we study how immune cells accumulate at inflamed sites, produce key cytokines, and contribute to disease pathology. Our research aims to uncover the signaling pathways that regulate immune cell recruitment, activation, and effector functions in chronic inflammation. We do so by utilizing spatial, high-dimensional proteomic imaging, Immunofluorescence microscopy, and spectral multicolor flow cytometry